Pre-Clinical

The RhinoChill® Intra-Nasal Cooling System has been examined in multiple pre-clinical studies. The following is a list of the published findings of these studies.

 

Effects of RhinoChill cooling in a healthy ovine model

• Preferentially cools the brain; safe and effective

Wolfson, et. al. Intranasal Perfluorochemical Spray for Preferential Brain Cooling in Sheep. Neurocrit Care. 2008;8(3)437-47.

 

Effects of RhinoChill intra-arrest cooling in a porcine model of cardiac arrest

• Cools the brain without circulation

Boller, et al. Feasibility of intra-arrest hypothermia induction: A novel nasopharyngeal approach achieves preferential brain cooling. Resuscitation. 2010;81(8):1025-30.

During CPR

  • Increases coronary perfusion pressure

Wang, et al. Intra-arrest selective brain cooling improves success of resuscitation in a porcine model of prolonged cardiac arrest. Resuscitation. 2010;81(5):617-21.

Yu, et al. Survival and neurological outcomes after nasopharyngeal cooling or peripheral vein cold saline infusion initiated during CPR in a porcine model of prolonged cardiac arrest. Crit Care Med. 2010; 38:916-21.

  • Increases the success of defibrillation shocks … which is characterized by measurably greater energy in the VF waveform

Tsai, et al Rapid head cooling initiated coincident with cardiopulmonary resuscitation improves success of defibrillation and post-resuscitation myocardial function in a porcine model of prolonged cardiac arrest. JACC 2008;51(20):1988-90.

Tsai, et. al. The amplitude spectrum area correctly predicts improved resuscitation and facilitated defibrillation with head cooling. Crit Care Med. 2008; 36: [Suppl.]:S413–S417.

Yu, et al. Nasopharyngeal cooling improves coronary perfusion pressure and amplitude spectrum area during CPR in comparison to systemic cold saline Infusion in a porcine model of prolonged cardiac arrest. Circulation. 2009; 120:S1452 (abstract)

  • Thus requires less adrenaline and less electrical shocks to be administered during ALS

Tsai, et al Rapid head cooling initiated coincident with cardiopulmonary resuscitation improves success of defibrillation and post-resuscitation myocardial function in a porcine model of prolonged cardiac arrest. JACC 2008;51(20):1988-90.

Yu, et al. Survival and neurological outcomes after nasopharyngeal cooling or peripheral vein cold saline infusion initiated during CPR in a porcine model of prolonged cardiac arrest. Crit Care Med. 2010; 38:916-21.

  • Increases ROSC rate

Wang, et al. Intra-arrest selective brain cooling improves success of resuscitation in a porcine model of prolonged cardiac arrest. Resuscitation. 2010;81(5):617-21.

Yu, et al. Survival and neurological outcomes after nasopharyngeal cooling or peripheral vein cold saline infusion initiated during CPR in a porcine model of prolonged cardiac arrest. Crit Care Med. 2010; 38:916-21.

After ROSC

  • Hastens cardiac recovery

Tsai, et al Rapid head cooling initiated coincident with cardiopulmonary resuscitation improves success of defibrillation and post-resuscitation myocardial function in a porcine model of prolonged cardiac arrest. JACC 2008;51(20):1988-90.

  • Hastens neurologic recovery

Guan, et al. Rapid induction of head cooling by the intranasal route during cardiopulmonary resuscitation improves survival and neurological outcomes. Crit Care Med. 2008; 36: [Suppl.]:S428 –S433.

  • Increases survival & neurologically-intact survival

Guan, et al. Rapid induction of head cooling by the intranasal route during cardiopulmonary resuscitation improves survival and neurological outcomes. Crit Care Med. 2008; 36: [Suppl.]:S428 –S433.

Yu, et al. Survival and neurological outcomes after nasopharyngeal cooling or peripheral vein cold saline infusion initiated during CPR in a porcine model of prolonged cardiac arrest. Crit Care Med. 2010; 38:916-21.